{"id":1263,"date":"2023-08-26T07:24:08","date_gmt":"2023-08-26T07:24:08","guid":{"rendered":"https:\/\/www.breastaware.gr\/?page_id=1263"},"modified":"2025-08-12T09:18:35","modified_gmt":"2025-08-12T09:18:35","slug":"%ce%bf%cf%81%ce%bc%ce%bf%ce%bd%ce%bf%ce%b8%ce%b5%cf%81%ce%b1%cf%80%ce%b5%ce%af%ce%b1","status":"publish","type":"page","link":"https:\/\/www.breastaware.gr\/en\/%ce%ba%ce%b1%cf%81%ce%ba%ce%af%ce%bd%ce%bf%cf%82-%ce%bc%ce%b1%cf%83%cf%84%ce%bf%cf%8d\/%ce%bf%cf%81%ce%bc%ce%bf%ce%bd%ce%bf%ce%b8%ce%b5%cf%81%ce%b1%cf%80%ce%b5%ce%af%ce%b1\/","title":{"rendered":"Endocrine Therapy"},"content":{"rendered":"<div id=\"pl-1263\"  class=\"panel-layout\" ><div id=\"pg-1263-0\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-1263-0-0\"  class=\"panel-grid-cell\" ><div id=\"panel-1263-0-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"0\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-1812\" src=\"https:\/\/www.breastaware.gr\/wp-content\/uploads\/2023\/08\/\u03958\u03b4_\u039f\u03a1\u039c\u039f\u039d\u039f\u0398\u0395\u03a1\u0391\u03a0\u0395\u0399\u0391-\u03ba\u03b5\u03af\u03bc\u03b5\u03bd\u03bf-400x400-1-300x300.jpeg\" alt=\"\" width=\"615\" height=\"615\" srcset=\"https:\/\/www.breastaware.gr\/wp-content\/uploads\/2023\/08\/\u03958\u03b4_\u039f\u03a1\u039c\u039f\u039d\u039f\u0398\u0395\u03a1\u0391\u03a0\u0395\u0399\u0391-\u03ba\u03b5\u03af\u03bc\u03b5\u03bd\u03bf-400x400-1-300x300.jpeg 300w, https:\/\/www.breastaware.gr\/wp-content\/uploads\/2023\/08\/\u03958\u03b4_\u039f\u03a1\u039c\u039f\u039d\u039f\u0398\u0395\u03a1\u0391\u03a0\u0395\u0399\u0391-\u03ba\u03b5\u03af\u03bc\u03b5\u03bd\u03bf-400x400-1-150x150.jpeg 150w, https:\/\/www.breastaware.gr\/wp-content\/uploads\/2023\/08\/\u03958\u03b4_\u039f\u03a1\u039c\u039f\u039d\u039f\u0398\u0395\u03a1\u0391\u03a0\u0395\u0399\u0391-\u03ba\u03b5\u03af\u03bc\u03b5\u03bd\u03bf-400x400-1.jpeg 400w\" sizes=\"auto, (max-width: 615px) 100vw, 615px\" \/><\/p>\n<p><strong>Hormone Therapy in Breast Cancer<\/strong><\/p>\n<p><strong>How it works, how it is administered and what are the possible side effects<\/strong><\/p>\n<p>The <strong>hormone therapy<\/strong> is a basic form of systemic treatment for women with <strong>hormone-dependent breast cancer<\/strong>, that is, when the growth of cancer cells is influenced by female hormones, such as <strong>estrogen and progesterone. <\/strong>Approximately <strong>7 out of 10 cases<\/strong> breast cancer are hormone-sensitive.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>How does hormone therapy work?<\/strong><\/p>\n<p>Treatment aims either at <strong>obstruction of action<\/strong> of hormones to the receptors of cancer cells either in the <strong>suspension of production<\/strong> of these hormones in the body. In this way, <strong>slows down or stops<\/strong> tumor progression and reduces the risk of disease recurrence.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>How is hormone therapy administered?<\/strong><\/p>\n<p>The <strong>Hormone therapy is mainly administered orally.<\/strong>, after surgery, and has <strong>duration 5 to 10 years<\/strong>, depending on each woman's risk profile. The most common pharmaceutical options are:<\/p>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"1\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\">Tamoxifen: Suitable for premenopausal and postmenopausal women.<\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"1\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"2\" data-aria-level=\"1\">Aromatase inhibitors (such as anastrozole, letrozole): are mainly indicated for postmenopausal women.<\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"1\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"3\" data-aria-level=\"1\"><strong>Combination<\/strong> of the above drugs in certain therapeutic protocols.<\/li>\n<\/ul>\n<p>In certain cases, hormone therapy may be started <strong>preoperatively,<\/strong> to reduce the size of the tumor.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Ovarian suppression in premenopausal women<\/strong><\/p>\n<p>For high-risk premenopausal women, ovarian function may be suppressed to stop estrogen production, achieved by:<\/p>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"2\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><strong>Pharmaceutical sedation<\/strong> (e.g. subcutaneous monthly injection of goserelin \u2013 Zoladex), which has the advantage of being reversible.<\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"2\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"2\" data-aria-level=\"1\"><strong>Surgical removal of the ovaries,<\/strong> in selected cases.<\/li>\n<\/ul>\n<p>Ovarian suppression may be accompanied by <strong>menopause symptoms,<\/strong> such as hot flashes, night sweats, irritability and <strong>vaginal dryness.<\/strong><\/p>\n<p>&nbsp;<\/p>\n<p><strong>What are the most common side effects?<\/strong><\/p>\n<p>Side effects vary with the drug and duration but often include:<\/p>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"3\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><strong>Hot flashes<\/strong> and night sweats<\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"3\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"2\" data-aria-level=\"1\"><strong>Vaginal dryness.<\/strong> and decreased libido<\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"3\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"3\" data-aria-level=\"1\"><strong>Arthralgias<\/strong> (joint pain)<\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"3\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"4\" data-aria-level=\"1\"><strong>Osteoporosis,<\/strong> especially with aromatase inhibitors<\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"3\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"5\" data-aria-level=\"1\"><strong>Increased risk of thrombosis or stroke, <\/strong>especially with tamoxifen<\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"3\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"6\" data-aria-level=\"1\"><strong>Endometrial cancer<\/strong> (in long-term use of tamoxifen)<\/li>\n<\/ul>\n<p>To prevent bone loss, regular orthopedic and endocrinological check-ups are important, as well as strengthening the diet with calcium and vitamin D.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>In summary<\/strong><\/p>\n<p>Hormone therapy is <strong>important therapeutic tool<\/strong> for the prevention of breast cancer recurrence in women with hormone-dependent tumors. The correct choice of regimen, good information and monitoring by the medical team ensure <strong>safer and more effective treatment<\/strong>.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Learn more at <a href=\"https:\/\/www.breastaware.gr\/en\/\">breastaware.gr<\/a><\/strong><\/p>\n<p>At <strong>breastaware.gr<\/strong> you\u2019ll find reliable, scientifically backed, and easy-to-understand information on all breast conditions, diagnosis, treatment options, and the importance of prevention. Stay informed, empowered, and take charge of your health!<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Scientific Sources:<\/strong><\/p>\n<ol>\n<li data-leveltext=\"%1.\" data-font=\"Times New Roman\" data-listid=\"4\" data-list-defn-props=\"{&quot;335552541&quot;:0,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769242&quot;:[65533,0],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;%1.&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\">National Comprehensive Cancer Network (NCCN) Guidelines<\/li>\n<li>Early Breast Cancer Trialists' Collaborative Group (EBCTCG),<\/li>\n<li data-leveltext=\"%1.\" data-font=\"Times New Roman\" data-listid=\"4\" data-list-defn-props=\"{&quot;335552541&quot;:0,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769242&quot;:[65533,0],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;%1.&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"3\" data-aria-level=\"1\">Burstein HJ et al., <i>Adjuvant Endocrine Therapy for Women With Hormone Receptor\u2013Positive Breast Cancer: ASCO Clinical Practice Guideline Focused Update<\/i>, <i>Journal of Clinical Oncology<\/i>, 2019.<\/li>\n<li data-leveltext=\"%1.\" data-font=\"Times New Roman\" data-listid=\"4\" data-list-defn-props=\"{&quot;335552541&quot;:0,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769242&quot;:[65533,0],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;%1.&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"4\" data-aria-level=\"1\">Gnant M. et al., <i>Ovarian Suppression in Premenopausal Breast Cancer: Current Status and Future Perspectives<\/i>, <i>ESMO Open<\/i>, 2021.<\/li>\n<li data-leveltext=\"%1.\" data-font=\"\" data-listid=\"4\" data-list-defn-props=\"{&quot;335552541&quot;:0,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769242&quot;:[65533,0],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;%1.&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"5\" data-aria-level=\"1\">American Cancer Society \u2013 Hormone Therapy for Breast Cancer<\/li>\n<\/ol>\n<\/div>\n<\/div><\/div><\/div><div id=\"pgc-1263-0-1\"  class=\"panel-grid-cell\" ><div id=\"panel-1263-0-1-0\" class=\"so-panel widget widget_pw_person_profile widget-person-profile panel-first-child\" data-index=\"1\" >\n\t<div class=\"person-profile  h-card\">\n\t\t\t\t\t\t<div class=\"person-profile__container\">\n\t\t\t<div class=\"person-profile__basic-info\">\n\t\t\t\t\t\t\t\t\t<h4 class=\"person-profile__name  p-name\">\n\t\t\t\t\t\t\t\t\t\tApostolos Mitrousias, MD, MSc\t\t\t\t\t\t\t\t\t\t<\/h4>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<div class=\"person-profile__label\">\n\t\t\t\t\t\tBreast 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aria-hidden=\"true\"><\/i>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"icon-list__text\">\n\t\t\t\t\t\t\t\t\tBreast Care Department \u2013 Secretary: Mirsini Tzamtzi\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t\t<a class=\"btn  btn-secondary  btn-block  person-profile__button\" href=\"mailto:info@breastaware.gr\" target=\"_blank\">Contact us<\/a>\n\t\t\t\n\t\t<\/div>\n\t<\/div>\n\n<\/div><div id=\"panel-1263-0-1-1\" class=\"so-panel widget widget_pw_opening_time widget-opening-time panel-last-child\" data-index=\"2\" ><div class=\"panel-widget-style panel-widget-style-for-1263-0-1-1\" >\t\t\t<div class=\"opening-time\">\n\t\t\t\t\t\t\t<div class=\"opening-time__item\">\n\t\t\t\t\t<div class=\"opening-time__day\">\n\t\t\t\t\t\tDaily\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"opening-time__time\">\n\t\t\t\t\t\t10:00-14:00 &amp; 17:00-21:00\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"opening-time__item\">\n\t\t\t\t\t<div class=\"opening-time__day\">\n\t\t\t\t\t\tSaturday\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"opening-time__time\">\n\t\t\t\t\t\t10:00 - 14:00\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t<\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>\u039f\u03c1\u03bc\u03bf\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c3\u03c4\u03bf\u03bd \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c4\u03bf\u03c5 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd \u03a0\u03ce\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b5\u03af, \u03c0\u03ce\u03c2 \u03c7\u03bf\u03c1\u03b7\u03b3\u03b5\u03af\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03c0\u03bf\u03b9\u03b5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf\u03b9 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ad\u03c2 \u03c0\u03b1\u03c1\u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2 \u0397 \u03bf\u03c1\u03bc\u03bf\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 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\u03cc\u03c0\u03c9\u03c2 \u03c4\u03b1 \u03bf\u03b9\u03c3\u03c4\u03c1\u03bf\u03b3\u03cc\u03bd\u03b1 \u03ba\u03b1\u03b9 \u03b7 \u03c0\u03c1\u03bf\u03b3\u03b5\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7. \u03a0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 7 \u03c3\u03c4\u03b9\u03c2 10 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd \u03b5\u03af\u03bd\u03b1\u03b9 &hellip;<\/p>","protected":false},"author":1,"featured_media":1583,"parent":1407,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":{"0":"post-1263","1":"page","2":"type-page","3":"status-publish","4":"has-post-thumbnail","6":"clearfix","7":"article"},"acf":[],"_links":{"self":[{"href":"https:\/\/www.breastaware.gr\/en\/wp-json\/wp\/v2\/pages\/1263","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.breastaware.gr\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.breastaware.gr\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.breastaware.gr\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.breastaware.gr\/en\/wp-json\/wp\/v2\/comments?post=1263"}],"version-history":[{"count":0,"href":"https:\/\/www.breastaware.gr\/en\/wp-json\/wp\/v2\/pages\/1263\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/www.breastaware.gr\/en\/wp-json\/wp\/v2\/pages\/1407"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.breastaware.gr\/en\/wp-json\/wp\/v2\/media\/1583"}],"wp:attachment":[{"href":"https:\/\/www.breastaware.gr\/en\/wp-json\/wp\/v2\/media?parent=1263"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}